Plasmochin in the Treatment of Malaria

Plasmochin in Malaria

Sir,?In your issue of the Gazette for August 1927 I find a very interesting article on "The Place of Plasmochin in the Treatment of Malaria" by Drs. Vad and Mohile of Bombay. In their series of experiments they have very carefully observed the crescenticidal effect of the new synthetic compound and have confirmed the claims made for Plasmochin in the treatment of malaria; but as the number of c...

Atebrin in the Treatment of Malaria in Railway Employees

Malariologist, Eastern Bengal Railway From the time of the discovery of cinchona up to 1926 when Professor Schulemann found a more effective anti-malarial remedy in a synthetic compound known as plasmochin, the only drugs that had been used effectively in the treatment of malarial fever were cinchona bark and the alkaloids obtained from it, particularly quinine. Plasmochin had little therapeuti...

Malaria and Its Treatment by the Synthetic Remedies: Atebrin and Plasmochin

A Case of Hæmoglobinuria Caused by Plasmochin Taken as a Prophylactic against Malaria

As far as I could make out from limited references no case has been recorded in which plasmochin, taken as a prophylactic against malaria, has resulted in hemoglobinuria. The interest in the following case lies in the fact that hemoglobinuria could be definitely attributable to the taking of plasmochin. The patient, an Indian sepoy (J. S.), aged 20 years, was one of the party of men from the l/...

Plasmochin as a Malarial Gametocide

It is needless to describe the chemical nature of the drug here and the literature on the subject of the treatment of malaria by the use of plasmochin is now too extensive to refer to in detail. The observations made by others may be summarised as follows :? (1) It has a destructive action on the trophozoites of P. vivax and P. malarice. (2) It has no such action on the trophozoites of P. falci...

Atebrin-Plasmochin in the Treatment of Malaria

The advent of atebrin and plasmochin into the realm of the chemotherapeusis of malaria was hailed with acclaim on all sides and the pendulum of public opinion swung rapidly upwards in favour of these new rivals to quinine. The new drugs were seized on with avidity, both by the medical profession and by the general public who were only too eager to escape from the thraldom of quinine, till then ...